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type="text/css"></style> <div id="ct" class="ct2 wp cl"> <div class="mn"> <div class="bm_haa cl"> <div class="bm_h cl"> <a href="http://www.oecr.com/portal.php?mod=rss&catid=62" class="y xi2 rss" target="_blank" title="RSS">订阅</a><h1 class="xs2">文章</h1> </div></div> <div class="kjkjb"> <div class="bm vw" style="margin-bottom:0;"> <div class="h hm"> <div class="zxtoux"><img src="http://www.oecr.com/uc_server/avatar.php?uid=54876&size=small" /></div> <h1 class="ph">拉曼光谱助力！新光学纳米孔器件有望用于快捷测序 </h1> <p class="xg1"> 时间：2018-6-6 10:28<a class="zz" href="home.php?mod=space&uid=54876">作者：update</a> 阅读<em id="_viewnum">(714)</em> 评论: <a href="http://www.oecr.com/portal.php?mod=comment&id=6714&idtype=aid" title="查看全部评论"><em id="_commentnum">5</em></a></p> <div class="zxfb" ><a href="http://www.oecr.com/portal.php?mod=rss&catid=62" class="y xi2 rss" target="_blank" title="RSS">订阅</a></div> </div> <!--[diy=diysummarytop]--><div id="diysummarytop" class="area"></div><!--[/diy]--> <div class="s"> <div class="ss"><div><span>导读： </span>比利时校际微电子中心(IMEC)近日发表公报说，该中心成功开发出一种能直接读取单分子DNA(脱氧核糖核酸)碱基的新型光学纳米孔器件，有望用于遗传学研究快捷测序。</div> </div> <!--[diy=diysummarybottom]--><div id="diysummarybottom" class="area"></div><!--[/diy]--> <div class="d"> <!--[diy=diycontenttop]--><div id="diycontenttop" class="area"></div><!--[/diy]--> <table cellpadding="0" cellspacing="0" class="vwtb"><tr><td id="article_content"><div> 比利时校际微<a href="http://electronic.oecr.com" target="_blank" class="relatedlink">电子</a>中心(IMEC)近日发表公报说，该中心成功开发出一种能直接读取单分子DNA(脱氧核糖核酸)碱基的新型光学<a href="http://material.oecr.com" target="_blank" class="relatedlink">纳米</a>孔器件，有望用于遗传学研究快捷测序。</div><div><br></div><div> 据介绍，新型器件结合了表面增强拉曼光谱和纳米孔流体技术，能以超高分辨率，实现无标记检测DNA中的遗传编码以及表观遗传变异。研究近期发表在英国《自然·通讯》杂志上。</div><div><br></div><div> 具体来说，这项技术通过纳米流体技术驱动DNA分子穿过一种拉长的纳米孔结构--表面等离子体纳米缝。而拉曼光谱是一种可反映分子特征结构的分子振动光谱。当DNA分子穿过纳米缝时，就会同时激发表面增强拉曼光谱，提供碱基分子的“指纹图”，以达到化学键水平的精准识别。</div><div><br></div><div> 据介绍，这种新型纳米孔器件不仅可以“读取”DNA编码，还可以“读取”碱基的各种化学修饰产物。这些修饰产物通常携带了与表观遗传变异相关的大量信息，同时它们也影响细胞中的基因表达，对进化研究和分析癌症等疾病的发展具有重要意义。</div><div><br></div><div> 表观遗传学是遗传学研究中最为前沿的领域之一，研究基因的DNA序列不发生改变的情况下，基因表达发生了可遗传的改变等现象。目前使用的表观遗传测序方法大都繁琐费时且价格昂贵。新型器件“是向开发可用于表观遗传学研究的快捷测序方案迈出的重要一步”，IMEC资深研究员陈昌博士说。</div><div><br></div><div> 比利时校际微电子中心成立于1984年，是一家在纳米电子、能源和数字技术研究和创新领域领先的独立研究中心，总部位于比利时鲁汶，并在荷兰、美国和中国等地拥有研发小组。</div><div><br></div><div><p microsoft="" yahei",="" simsun;="" background-color:="" rgb(255,="" 255,="" 255);="" text-align:="" center;"="" center;="" 255);"="" style="text-align: center; word-wrap: normal; margin: 0px; padding: 0px; color: rgb(143, 143, 143); font-family: Tahoma, "Microsoft Yahei", Simsun; background-color: rgb(255, 255, 255);"><b style="word-wrap: normal;"><font size="5" style="word-wrap: normal;">欢迎关注OECR公众号</font></b></p><p microsoft="" yahei",="" simsun;="" background-color:="" rgb(255,="" 255,="" 255);="" text-align:="" center;"="" center;="" 255);"="" style="text-align: center; word-wrap: 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